Primary Hyperparathyroidism: An Overview

Primary Hyperparathyroidism: An Overview

Primary hyperparathyroidism is a common condition that affects 0.3% of the general population. Primary and tertiary care specialists can encounter patients with primary hyperparathyroidism, and prompt recognition and treatment can greatly reduce morbidity and mortality from this disease. In this paper we will review the basic physiology of calcium homeostasis and then consider genetic associati...

Hyperparathyroidism: An Overview

The four parathyroid glands, normally located behind the four poles of the thyroid gland, secrete parathyroid hormone (PTH), which regulates extracellular calcium levels. Hyperparathyroidism, which can be primary, secondary, tertiary or quaternary, results in excess production of PTH. Excessive PTH secretion may be due to hyper-function in the glands themselves, in which case it is referred to ...

Primary Hyperparathyroidism and Pancreatitis: an Uncommon Cause of Pancreatitis

An instructive case suggesting cyclical primary hyperparathyroidism.

We report an instructive case of primary hyperparathyroidism in which cyclical secretion of PTH may have caused repeated hypercalcemic crises followed by temporary remission with a spontaneous drop in PTH. A 64-year-old man was admitted to our hospital twice with severe hypercalcemic crisis (corrected calcium (cCa) 15.0 mg/dl and 16.7 mg/dl) accompanied by an increase in intact PTH (220 pg/ml a...

Immunologic Differentiation of Primary Hyperparathyroidism from Hyperparathyroidism

A B S T R A C T Serum immunoreactive parathyroid hormone (IPTH) was measured by radioimmunoassay in 54 patients with primary hyperparathyroidism and in 18 consecutive patients with ectopic hyperparathyroidism due to nonparathyroid cancer without apparent skeletal metastasis. Although serum calcium concentration was higher in the group with ectopic hyperparathyroidism, serum IPTH was lower (rank...